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As research advances, the antioxidant system has progressively been categorized into two distinct types: those dependent on GPX4 and those independent of GPX4, which will be detailed below

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If the efficacy of l-glutamine supplementation is dramatically impacted by the presence or absence of other amino acids metabolised by the enterocytes, this would possibly explain, at least in part controversial results obtained in human subjects and animal models supplemented with l-glutamine and submitted to exercise