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In I/R models, lactate released by the kidney enters the liver through portal vein, where it activates pyruvate carboxylase (PC) and phosphoenolpyruvate carboxykinase (PEPCK), thereby promoting glucose synthesis (Yu et al., 2021)

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Disclosures: Grace Chee: Gilead Sciences: Employee, Soo Aleman: Gilead: Speaking and Teaching, Maurizia Brunetto: Nothing to Disclose, Antje Blank: Gilead: Contract for study conduct of Myr301 with Gilead Sciences, Myr GmbH: Research support and provision of documents for bulevirtide, Pietro Andreone: Nothing to Disclose, Pavel Bogomolov: Nothing to Disclose, Vladimir Chulanov: Nothing to Disclose, Nina Mamonova: Nothing to Disclose, Natalia Geyvandova: Nothing to Disclose, Morozov Viacheslav: Nothing to Disclose, Olga Sagalova: Hepatera, R-Pharm: Speaking and Teaching, Tatyana Stepanova: Nothing to Disclose, Dmitry Manuilov: Nothing to Disclose, Sarah Arterburn: Gilead Sciences Inc: Employee, Gilead Sciences Inc: Stock – privately held company, Gilead Sciences Inc.: Stock - publicly traded company, Audrey Lau: Nothing to Disclose, Anu Osinusi: Nothing to Disclose, Florence Christian-Cox: Gilead Sciences INTL: Employee, Frank Duff: Nothing to Disclose, Julian Schulze Zur Wiesch: Nothing to Disclose, Markus Cornberg: Nothing to Disclose, Stefan Zeuzem: Nothing to Disclose, Heiner Wedemeyer: Nothing to Disclose, Pietro Lampertico: ROCHE PHARMA/DIAGNOSTICS, GILEAD SCIENCES, GSK, ABBVIE, JANS: Advisor 163 THE VIRAL ENVELOPE GLYCOPROTEIN GP120 FACILITATES A PROFIBROTIC PROGRAM FOLLOWING HIV EXPOSURE IN THE LIVER Volney Spalding 1 Shadi Salloum 1 Raymond Chung 2 Brian Fellenstein 1 Min Xu 1 Charlotte Warner 1 Nadia Alatrakchi 1 Wenyu Lin 2 , 1 Massachusetts General Hosptial, 2 Massachusetts General Hospital Background: The successful implementation of antiretroviral therapy (ART) has shifted the focus of HIV-1 research towards the long-term effects of persistent, controlled infections