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doi: 10.1007/s11356-014-3885-5

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High CpG-density Promoter (HCP): A range of 500 bp region exists in the promoter between −0.7 kb (upstream 0.7 kb) and + 0.2 kb (downstream 0.2 kb) of transcription initiation site (TSS), the (G + C)-fraction in this range is ≥ 0.55, and the observed/expected (O/E) of CpG is ≥ 0.6