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For instance, a pilot randomized controlled trial on healthy adults showed that a magnetic field of 50 Hz had therapeutic effects to stimulate parasympathetic activity, resulting in enhanced vasodilation and blood flow through a nitric oxide-dependent mechanism (Okano et al., 2021)

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The following subsections are focused on a brief view of basic characteristics of NPs (Section 3.1), the most important/frequently used procedures for the preparation of CS NPs (Section 3.2), types and properties of CS-based nanocomposites (Section 3.3), and recent applications of CS NPs in drug delivery (Section 3.4)