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NICE-approved weight management interventions include: Dietary and lifestyle modification – first-line approach for all patients Orlistat – licensed medication for obesity (BMI ≥30 or ≥28 with comorbidities) GLP-1 receptor agonists – including semaglutide (Wegovy) per NICE TA875 and liraglutide (Saxenda) with restrictions per NICE TA664, for specific patient groups Bariatric surgery – for severe obesity meeting strict criteria The NHS emphasises that sustainable weight loss requires behavioural change, nutritional education, and increased physical activity

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Research investigating pH-dependent conformational changes could elucidate stability mechanisms