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As shown in Table 1 and Figure 6, in the pursuit of structurally diverse NNMT inhibitors, researchers have identified certain macrocyclic peptides that bind to NNMT, displaying potent inhibition with Half-maximal inhibitory concentration (IC 50 ) values as low as 229 nM ( 5 Implications and recommendations for future research As delineated in the text, NNMT is a crucial factor in MetS and has become a promising target for preventing or treating MetS-related diseases