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As during abiotic and biotic stresses, polyamines are transported into the apoplast, where they are catabolized to generate hydrogen peroxide, while at low levels of hydrogen peroxide these act as signalling molecules to activate ROS dependent protective pathways to enhance tolerance in plants to abiotic stresses and killing of the pathogen in cases of infection [89,90]

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Most patients begin noticing changes in abdominal circumference between weeks 8 and 12