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In summary, Raman scattering techniques, especially SERS and its derivatives, have proven to be powerful tools for SMD in diverse fields, including biomedical diagnostics, proteomics, metabolomics, and environmental sensing

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Gro3P accumulation has been identified as a key metabolic feature under NADH-reductive stress, whether induced by the expression of our recently developed genetic tool Ec STH (a soluble transhydrogenase that deposits electrons on NAD + using reducing equivalents of NADPH), mitochondrial ETC dysfunction or hypoxia, or by failed pyruvate to lactate conversion via disrupted LDH 12–15