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Benefits are most plausible during periods of extremely intense training (e.g., overtraining) where immune suppression and glutamine depletion are more likely, or in endurance athletes concerned about exercise-induced gut permeability [27][31][33]

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Riboflavin is also essential for the metabolism of homocysteine, as a cofactor for methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) (11)