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First , for the purposes of determining whether the concentration of a Section 4 Substance is high enough to amount to an anti-doping rule violation, Anti-Doping Organisations (“ ADOs ”) rely on the concentration estimates reported by the relevant WADA-accredited laboratories, rather than a Validated Quantification Procedure as used to assess the concentration of Threshold Substances

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The C-terminus of TDP-43 has an intrinsically disordered area that can produce amyloid fibrils