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Cytokines initiate downstream inflammatory signaling pathways, such as the Janus kinase/signal transducer and activator of transcription (JAK/STAT), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathways, resulting in the activation of inflammatory gene expression (Zhang et al., 2024[125])

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A systematic review of 13 clinical studies also supported these findings [72]