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40 , 42 Cagrilintide also exhibited a rapid dissociation with a residence time of 3–6 min 28 that is comparable for all AMYRs whereas sCT showed slow rates of dissociation from all receptors (45–60 min) confirming previous studies performed in vivo and in vitro .51, 52, 53 This effect was associated with a longer duration of action of the peptide in cAMP production with a sustained response for sCT while cagrilintide’ cAMP activation returned to baseline within a few hours

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