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The 16th-edition annual banned-substance review by Thevis, Kuuranne, and Geyer, published in Drug Testing and Analysis in 2024, surveyed analytical approaches in human sports drug testing across 2022–2023 and catalogued emerging metabolic modulators — including ERR-pathway agents — as substances warranting heightened anti-doping surveillance

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If a researcher adjusts their protocol upward to compensate for suspected underdosing and subsequently switches to a more accurately dosed source, the actual dose received could be significantly higher than intended