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Although not as statistically meaningful, other supplements were associated with the following increases in the risk of death during the study: multivitamins (2.4%), vitamin B6 (4.1%), folic acid (5.9%), magnesium (3.6%), zinc (3.0%), and copper (18.0%)

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In pancreatic ductal carcinoma cells, suppression of GPx1 expression promoted ROS-induced Akt signaling (measured by Akt phosphorylation) to drive an epithelial-mesenchymal transition that is associated with enhanced tumor growth, whereas overexpression of GPx1 decreased the phenotypic changes in pancreatic ductal carcinoma cells by decreasing ROS-mediated pro-survival signaling in these cells [134]