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Males tend to have higher systemic iron levels than females due to the absence of menstrual iron loss, which might predispose them to greater ferroptotic vulnerability and increased iron accumulation in VCID-related brain regions (e.g., hippocampus, deep gray matter) (Allegra et al., 2024)

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The improved efficacy was likely due to a decrease in insulin and its ability to re-activate PI3K in the tumor cells, the researchers wrote