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It turns out that even in mice that lack these receptors, fat loss takes place when AOD9604 is administered Though the beta-3-adrenergic receptor likely plays a role in fat loss secondary to AOD9604, at least one other mechanism must be in play as well

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The nasal mucosa is well vascularized, and absorption begins quickly after administration, with detectable levels in CNS tissue sometimes within minutes of intranasal dosing.For applications where a longer window of action at a lower dose is preferred over a sharp injection peak, nasal delivery can produce a different pharmacokinetic profile that some peptide protocols are designed around