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6 Nanoparticles regulate MDSCs MDSCs are a heterogeneous population of immature myeloid cells, which play a vital role in promoting tumor progression, metastasis, and the production of immunosuppressive TME, and are associated with treatment resistance and poor prognosis of malignant tumors, and the elimination of immunosuppression of MDSCs is beneficial to restore anti-tumor immunity (117, 118)

1 LR3 protein has been specifically engineered for higher biological potency and is used in the maintenance of human pluripotent stem cells.