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Systematic studies in early treated children with cblC reveal that nearly half of the cases experienced seizures and more than three-quarters of the children had MRI brain abnormalities by age four, and developmental quotients progressively declined with age in untreated segments, underscoring the impact of metabolic decompensation on neurodevelopment (28, 29)

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Piperine and its Metabolite's pharmacology in neurodegenerative and neurological diseases