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Additionally, a large portion of the glutathione is broken down in the digestive tract before it reaches the cells

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found that downregulation of ALPK1 expression in HK-2 cells reversed the upregulation of high glucose-induced expression of cellular pyroptosis-related proteins and the increase of cellular pyroptosis ( In summary, initially, inflammatory cytokines function locally—either affecting neighboring cells (paracrine) or acting on the same cells that produce them (autocrine)—to initiate the epithelial-to-mesenchymal transition in the kidneys