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Notably, the apoptotic effects of salusin-β overexpression in these cells were reversed by inhibitors such as Go 6976 (a PKC inhibitor), N-acetylcysteine (a ROS scavenger), apocynin (an NADPH oxidase inhibitor), and pifithrin-α (a p53 inhibitor)

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Moreover, riboflavin pathway derivatives, such as 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU), 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 6,7-Dimethyl-8-(1-D-ribityl)lumazine (RL-6,7-diME), function as evolutionarily conserved non-peptidic antigens to a subpopulation of innate-like T cells, Mucosal Associated Invariant T (MAIT) cells, particularly enriched at mucosal surfaces of mammals, such as the gut, bronchea, skin and uterus 187,188,189

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