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This recognition is mediated by specialized molecular sensors, including pattern recognition receptors (PRRs), activated by damage-associated molecular pattern (DAMP) molecules produced upon exogenous threats and endogenous danger signals, subsequently activating inflammatory cascades [141, 142]

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In addition, pre-surgery is a good time to initiate consultation with a plastic surgeon regarding options of removal of excess skin removal once weight stability is established post-operatively (usually between 1 and 3 years)