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GS, expressed specifically in astrocytes, converts glutamate (which is synthesized in astrocytes from glucose) to biologically inactive glutamine, which is exported to extracellular space by Na + -dependent neutral amino acid transporters SNAT3 and SNAT5 (SLC38A3 and SLC38A5) and imported into neurons by SNAT1 and SNAT2 (SLC38A1 and SLC38A2) 434,435

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found an inverse correlation between GLS1 and E-cadherin expression by analyzing seven CRC cell lines