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Unlike oxyntomodulin-based dual agonists such as mazdutide — which derive their dual receptor activity from the natural GLP-1R/GCGR promiscuity of the 37-AA OXM proglucagon fragment — survodutide engineers GLP-1R potency directly into a shorter glucagon-derived backbone through targeted amino acid substitutions, enabling a pharmacologically distinct receptor engagement profile in vitro

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[DOI] [PubMed] [Google Scholar] 428.Yang H, Wang H, Ren J, Chen Q, Chen ZJ