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peptidoglycan and lipoteichoic acid have shown more pronounced activity than the cell wall and induced innate immunity in fish (Yang et al., 2019)

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In another study that investigated the effects of oral supplementation with Ala-Gln and glutamine (Gln) on dextran sulfate sodium (DSS)-induced colitis in mice [55], both supplements significantly improved colitis symptoms, such as bodyweight loss and colon damage, reduced inflammation markers and tissue apoptosis, and enhanced gut microbiota diversity and function, with Ala-Gln demonstrating superior efficacy over Gln in preserving intestinal integrity and microbiota composition [55]

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