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Most recently, a 2026 paper in Cell Reports (PMID 41543936) implicated NNMT in tubular senescence and fibrosis in early chronic kidney disease and found selective inhibition protective in senescent kidney cells, organoids and in vivo

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However, these trials did not isolate tirzepatide's direct hormonal effect from the period disruption caused by rapid weight loss alone, which is a known phenomenon in any aggressive calorie deficit