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48–50 Approaches that directly target cccDNA (eg, CRISPR/Cas9 50 or other gene editing methodologies 51 ) have shown promising results in laboratory studies, but issues including hepatocellular delivery, off-target effects, and the likelihood that they will also cleave chromosomally integrated HBV DNA and thus trigger unpredictable consequences of chromosomal DNA recombination will need to be carefully considered

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He introduced the concept of metabolic cardiology, pioneered the use of COQ10 in reversing previously untreatable cardiac conditions, and was among the first to recognize the healing power of food when it comes to heart health