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Here, Wnt signaling-mediated inhibition of GSK-3β activity increases the amount of β-catenin, which enters the nucleus, and associates with T-cell factor/lymphoid enhancer binding factor (TCF/LEF) transcription factors, leading to the transcription of Wnt target genes involved in cell survival, proliferation, and differentiation

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In vitro studies showed α-tocopheryl phosphate and α-tocopheryl succinate (two forms of α-tocopherol supplementation) inhibited GSTO1 activity in a concentration-dependent manner [206,208]