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The remaining fraction is represented by nonprotein-binding disulfides, which include Hcy, homocysteine–cysteine disulphide, and lesser amounts of other mixed disulfides, such as homocysteine–cysteinylglycine disulfide (described as Hcy-SS-R) [59]

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From a drug development perspective, targeting the transition from droplet-state sensors to ordered inflammasome assemblies—by raising the energy barrier for this conversion—may potentially suppress pathological pyroptosis while preserving host defense functions