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POL a natural stilbenoid, has been shown to promote osteogenic differentiation in BMSCs and upregulate angiogenesis-related gene expression through activation of the PI3K/Akt/GSK-3β/β-catenin signaling pathway (Zhou et al., 2025)

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This article explores the biochemistry behind these compounds and the evidence supporting their use, particularly for aging populations and those facing elevated oxidative stress