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Cells were fed every 3 days by removing half of the culture medium and replacing it with fresh cRPMI

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Glossary Abbreviations 17α-OHP 17α-hydroxyprogesterone 17βHSD2 17β hydroxysteroid dehydrogenase 2 5α-DHP 5α-dihydroprogesterone 5β-DHP 5β-dihydroprogesterone ACTH adrenocorticotropic hormone ADAM12 ADAM metallopeptidase domain 12 AF activation function AIB1 amplified in breast cancer 1 AKAP13 A-Kinase Anchoring Protein 13 AKR1B1 Aldo-keto reductase family 1 member B1 AP-1 activator protein 1 ATBF1 AT Motif-Binding Factor 1 or zinc finger homeobox 3 Bax BCL2 associated X, apoptosis regulator BBSS Biberoglu & Behrman Symptom Severity Bcl-2 B-cell lymphoma BMAH bilateral macronodular adrenal hyperplasia cAMP cyclic adenosine monophosphate CDKI cyclin-dependent kinase inhibitor COX-2 cyclooxygenase-2 Cu-IUD copper intrauterine device CYP cytochrome P450 DBD DNA binding domain E2 estrogen EC emergency contraception ECM extracellular matrix EMA European Medicines Agency EMMPRIN extracellular matrix metalloproteinase inducer ERBB2 epidermal growth factor 2 FAK focal adhesion kinase FASLG Fas ligand FDA Food and Drug Administration FOXO1 forkhead Box O1 FSH follicle stimulating hormone GABA A aminobutyric acid type A GADD153 DNA-damage-inducible gene 153 GSK3β glycogen synthase kinase 3β GSTM1 glutathione-s transferase mu 1 H hinge region HAND2 heart and neural crest derivatives expressed 2 HDACi histone deacetylase inhibitor HIF-1α hypoxia-inducible factor-1alpha HMB heavy menstrual bleeding HRQL health-related quality of life HSP heat shock protein IGFBP-1 insulin-like growth factor binding protein 1 IL-15 interleukin 15 KLF11 krüppel-like transcription factor 11 LAT2 L-type amino acid transporter 2 LBD ligand-binding domain LGESS low grade endometrial stromal sarcoma LH luteinizing hormone MAPK mitogen-activated protein kinase MKP-1/DUSP1 MAPK phosphatase 1 MMP matrix metalloproteinase MPA medroxyprogesterone acetate mPR membrane-bound progesterone receptors MR mineralocorticoid receptor MT1-MMP membrane type 1-MMP NETA norethisterone acetate NFAT5 nuclear factor of activated T-cells NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells NLS nuclear localization signal NTD N-terminal A/B domain P4 progesterone PAEC progesterone receptor modulator-associated endometrial change PARP poly(ADP-ribose) polymerase cleavage PBAC pictorial blood assessment chart PCNA proliferating cell nuclear antigen PGE2 prostaglandin E2 PGL4002 mono-N-demethylated metabolite PGL4004 di-N-demethylated metabolite PI3K/AKT phosphatidylinositol 3-kinase PKC protein kinase C PLAU plasminogen Activator, Urokinase PR progesterone receptor PRE progesterone response elements PRL prolactin PXR pregnane X receptor RANKL Receptor activator of nuclear factor kappa-Β ligand or TNF superfamily member 11 SEISMIC Study of the Efficacy and Safety of Mifepristone in the Treatment of Endogenous Cushing’s Syndrome SLC5A3 solute carrier family 5 member 3 SMRT silencing mediator of retinoid and thyroid hormone receptor Sp1 specificity protein1 SPRM selective progesterone receptor modulator SRC steroid receptor coactivator-1 STAT5 signal transducer and activator of transcription 5 TEAE Treatment-emergent adverse effect TGF-β transforming growth factor-β THY1 Thy-1 cell surface antigen TIMP tissue inhibitor of MMP TNBC Triple-negative breast cancer TN-C tenascin C TNF-α tumor necrosis factor-α TRPS1 Transcriptional Repressor GATA Binding 1 TUNEL terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling UFS-QoL Uterine Fibroid Symptoms Quality of Life Questionnaire UPA ulipristal acetate VEGF vascular endothelial growth factor Additional Information Disclosure Summary : J.S

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