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One study showed that after 10 weeks of treatment with a polyphenol alcohol extract, 14 pediatric CD patients experienced a significant decrease in blood thromboxane levels—a key factor promoting platelet aggregation and vasoconstriction—which may help reduce inflammation and improve gut health ( Research in CD patients in remission found that Pycnogenol® (French maritime pine bark extract), while not significantly affecting conventional inflammatory markers or disease activity indices, improved iron metabolism markers (increased transferrin, decreased ferritin), indicating a potential role in regulating the frequently disrupted iron homeostasis in CD

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