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47 , 48 In conclusion, melatonin has a variety of neuroprotective benefits on Parkinson’s disease (PD) via a number of pathways (Figure 3), such as its anti-inflammatory, antioxidant, and circadian rhythm-modulating effects as well as its influence on autophagy and mitochondrial function

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As for thermal effect, the energy conversion from ultrasonic wave to thermal energy inside biological tissues contributes to the breakup of polymer backbone leading to drug release