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Because mechanisms for paclitaxel-induced changes in neuronal sensitivity may differ between rodents and humans, research on human primary neurons and neuron-like cells induced from human pluripotent stem cells has surged in recent years

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A study using fluorogenic peptide substrates found that caspase-4, -5 and -11 substrate specificity for GSDMD is influenced by prime side amino acids P1′- P4′, while caspase-1 substrate affinity is mostly influenced by the P1-P4 sequence (Bibo-Verdugo et al., 2020)