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Thus, akin to ApoE mediating Onpattro’s targeting of the liver, other serum proteins could mediate these LNPs to different organs or tissues ( In their research, another group of scientists achieved the absorption of different serum proteins with different compositions on the surface of LNPs by modifying the chemical structure of ionizable cationic lipids (Qiu et al., 2022

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However, some may experience mild discomfort at the injection site, such as slight swelling or redness