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This was reminiscent of the genetically engineered NF1-OPG mice in which neuroglial progenitor cells could serve as initiating cells of optic glioma formation (82, 92)

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Moreover, because much of the DHA detected in tissues is probably localized in the apoplast rather than the cytosol, we can assume that plant cells are able to maintain very high cytoplasmic ascorbate-DHA ratios simultaneously with low GSH-GSSG ratios, presumably because of efficient GSH-independent pathways of ascorbate regeneration and/or the difference in redox potential between the GSH/GSSG and ascorbate/DHA couples (Fig

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