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Chronic administration of high doses of oral levocarnitine in patients with severely compromised renal function or in ESRD patients on dialysis may result in accumulation of the potentially toxic metabolites, trimethylamine (TMA) and trimethylamine-N-oxide (TMAO), since these metabolites are normally excreted in the urine

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In other model systems, maintained rates of fatty acid beta-oxidation with aging have been linked with longevity, while the lifespan extension in response to DR has been shown to occur through a similar mechanism as the lifespan extension that occurs by overexpression of fatty acid beta-oxidation pathway genes in Drosophila (Doering et al., 2023