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Nonetheless, research has looked into the correlation between the mutation and the following conditions: • Thromboembolic and heart diseases like blood clots, heart attacks, and stroke • Depression, anxiety, bipolar disorder, schizophrenia, and autism • Autoimmune conditions and thyroid problems • Colon cancer and leukemia • Chronic pain and fatigue, nerve pain, and migraines • Recurrent miscarriages, neural tube defects like spina bifida • Digestive issues like IBS • Hormone problems like PCOS Various different genetic tests can assess for the MTHFR mutation and tend to be very expensive
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Gupta, Gill, Andrews, and Prausnitz, working in human subjects and published in the Journal of Controlled Release in 2011, used electrical impedance to track how quickly skin reseals its barrier after microneedle insertion, and found that in the absence of occlusion, treated sites recovered their barrier properties quickly, on the order of a couple of hours