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Reprogramming of urea cycle in cancer: Mechanism, regulation and prospective therapeutic scopes

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Additional topical options demonstrate varying mechanisms: Kojic acid 1-4%: Daily application with moderate tyrosinase inhibition Vitamin C serum 10-20%: Daily application with weak to moderate tyrosinase inhibition Tranexamic acid 2-5%: Twice daily application using anti-inflammatory mechanisms Systematic reviews document superior efficacy with combination therapy using oral plus topical glutathione versus monotherapy