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Other limitations include the fact that the in vitro granuloma model used is not an exact replication of in vivo granulomas which have a more complex and dynamic environment containing other cells like fibroblasts, collagen matrix, and other white blood cells

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The article says oral glutathione has limited bioavailability, meaning much of what is swallowed does not reach circulation in a useful form, and that evidence for its specific health claims is modest at best