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Moreover, several patents have been registered in relation to the therapeutic applications of melatonin and melatonin analogues (sleep disorders, neuroprotection, cancer)

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Interestingly, the former is ASXL1 EBM, and the latter is ASXL1 MBH , indicating that these regions are performed for binding of BRD4 ET and MLL4 PHD2/3 , as in the respective complexes, ASXL1 EBM is bound as a β-strand and ASXL2 MBH 10 is bound as an α-helix (Fig