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Docking was directed to the GluN1/GluN2B ligand-binding domain (LBD), based on blind docking predictions using CD-DOCK and functional data indicating that the ATD was not involved in EAR-20 activity

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This review will focus on the roles of NNMT in obesity and T2D, as it has been found that the expression of this methyltransferase is elevated in the white adipose tissue and liver of obese people and diabetic mice and that NNMT knockdown protects against diet-induced obesity and insulin resistance [11]