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proposed that the complex facilitates copper uptake into cells.[8] Reported activities in fibroblast and skin models include stimulation of collagen synthesis, modulation of MMP-2 expression, and effects on MMP/TIMP balance and matrix proteins.[11][13] Pickart and colleagues also reported broad gene-expression modulation and antioxidant-gene regulation.[9][10][14] 3

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Congratulations to Aniketh Bishnu, Juan Zapata Muñoz, Rob Taylor, Kei Sakamoto, Ian Ganley, and colleagues on this important advance in mitochondrial biology and rare disease research