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For the reasons stated earlier in this section of this final rule, we continue to believe that the proposed approach strikes a balance between (1) policies that support growth of the Shared Savings Program by allowing for participation under a one-sided model for up to the entirety of an eligible ACO's first agreement period, and (2) policies encouraging participation in performance-based risk which we believe have the potential for increased effectiveness towards meeting the program's goals

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DAO also modulates type II alveolar epithelial cell senescence via the p53/p21 pathway