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During myocardial ischemia-reperfusion injury, FSTL1 may counteract nuclear receptor subfamily 4 group A member 1-mediated fission and promote FUN14 domain-containing 1-mediated mitophagy, helping to maintain mitochondrial networks (108)

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CYP2C8 is the second most important cytochrome after CYP3A4 for the conversion of buprenorphine to its active metabolite, norbuprenorphine (Picard et al., 2005), and its expression is under genetic control