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demonstrated that antioxidant vitamin therapy, including vitamin A at 417 U/kg, ameliorated myocardial apoptotic activity and reduced inflammatory signaling pathways associated with septic pathophysiology (Carlson et al., 2006)

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It is suggested that melatonin influences SIRT1 through its specific receptor MT1, blocking the transcription of BMAL1 and therefore SIRT1 via inhibition of RORα (Figure 2) [142]