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Figure 1 2.2 System xc − -GPX4 axis failure and lipid peroxidation The System Xc − -GPX4 axis plays a crucial role in maintaining cellular redox homeostasis ( − is responsible for importing cystine, which is subsequently reduced to cysteine, facilitating the synthesis of GSH

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Several studies have investigated the prevalence of vitamin B 12 deficiency and its associated factors among patients with T2DM who are on metformin [20, 29–31]