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A sigma class glutathione S-transferase gene regulated by the CncC pathway is required for phytochemical tolerance in the red flour beetle, Tribolium castaneum - ScienceDirect

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More broadly, the present findings establish SMG1 as a multifunctional stress-response kinase whose inhibition simultaneously disrupts NRF2-dependent redox buffering, NMD-mediated suppression of tumor neoantigen expression, and Regnase-1-dependent inflammatory mRNA decay to remodel the tumor microenvironment—three mechanistically independent outputs converging on a single molecular target

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