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As a marker of cccDNA and HBV translation, serum HBcrAg correlates well with the transcriptional activity of intrahepatic cccDNA and thus can monitor the efficacy of the new HBV regimens targeting cccDNA

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The mentioned data suggest that further research is needed to identify specific patterns that may help to segregate pathways of lung and systemic injury or direct and indirect ARDS, respectively [14]