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First, the presence of aggregates of T and B lymphocytes in the lung parenchyma of smokers that correlate with disease severity indirectly supports the role of the adaptive immune system in disease progression 67,68

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Different tests have experimented with the effectiveness of various species of probiotics in intestinal permeability, including Lactobacillus rhamnosus GG, Lactobacillus acidophilus , Lactobacillus Plantarum , Bifidobacterium infantis , Bifidobacterium animalis lactis BB-12, and Escherichia coli Nissle 1917 [120] (Table 1)