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In this 8-week randomized controlled trial in 100 adults with depression (50 men and 50 women), daily supplementation with creatine monohydrate improved depression symptoms more than a placebo.⁠ ⁠ These results add

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In this study, both Met and L-car ameliorated adipocyte swelling and fat vacuole enlargement reversed the downregulation of BAT-specific UCP1 and adipose tissue-localized PRDM16, UCP1, and PGC1α and dampened upregulation of IL-6 and TNF-α in the abdominal subcutaneous adipose tissues of obese rats